Jarell Quansah is expected to start at right-back for England in their World Cup last-16 showdown with Mexico as Thomas Tuchel deals with a growing defensive headache.
The Bayer Leverkusen defender is set to be named in the starting XI at the Azteca Stadium, with Djed Spence struggling after reporting a muscle issue on Sunday morning.
England are already without Reece James, who has missed the past two matches after sustaining a hamstring problem late in the goalless group-stage draw with Ghana.
The Chelsea captain has not yet returned to full training and was the only member of the squad absent from Saturday's session in Mexico City.
The Football Association said James was working on an individual programme away from the main group, while Tuchel admitted he would require a late fitness assessment before any decision was made over whether he could make the bench against Mexico.
Quansah's expected inclusion represents a significant call from Tuchel, with England's right-back situation having become one of the major talking points of their tournament.
Jarell Quansah is expected to start at right-back for England in their World Cup last-16 showdown with Mexico as Thomas Tuchel deals with a growing defensive headache
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Newcastle defender Tino Livramento was forced to withdraw from the squad before the World Cup began because of a calf injury.
Tuchel then opted to replace him with Chelsea centre-back Trevoh Chalobah rather than selecting a specialist right-back, a decision that has attracted scrutiny as the tournament has progressed.
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England's record at the World Cup | GETTY/ GB NEWSSpence had previously been used at left-back in England's draw with Ghana and came off the bench in victories over Croatia and Panama.
However, his latest fitness concern appears to have opened the door for Quansah to start in an unfamiliar role.
England are also expected to make changes further forward.
According to the BBC, Bukayo Saka and Anthony Gordon are in line to return to the side, replacing Noni Madueke and Marcus Rashford on the flanks.
England boss Thomas Tuchel is poised to bring Bukayo Saka and Anthony Gordon into the side for tonight's World Cup match with Mexico
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The winner of Monday morning's tie will progress to the World Cup quarter-finals, with England hoping to build on a campaign that has so far produced mixed performances despite reaching the knockout stages.
Tuchel's side topped their group but have been forced to solve several selection issues, particularly in defence.
Ezri Konsa remains another possible option at right-back, though he has started all four of England's matches so far in central defence.
How the Three Lions fare remains to be seen.